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The therapeutic effect of SFB@(HB㊏EUD) on DR. (A) Results of the HET-CAM assay. (B) Body weight and blood glucose levels in different treatment mice groups. (C) The images of mice ocular tissues of FP, FFA and H&E histological evaluation of mice retina at 400×; GCL, (IPL) Inner plexiform layer, (INL) Inner nuclear layer, (OPL), Outer plexiform layer, ONL, (PRL) Photoreceptor layer. (D) Relative <t>VEGF</t> protein expression levels in retinal tissues of mice, as determined by Western blotting and normalized <t>to</t> <t>β-actin.</t> All data were presented as mean ± SD ( n = 6), p values were determined using an unpaired, two-tailed Student's t -test, ** p < 0.01.
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rabbit anti vegf  (Servicebio Inc)
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The therapeutic effect of SFB@(HB㊏EUD) on DR. (A) Results of the HET-CAM assay. (B) Body weight and blood glucose levels in different treatment mice groups. (C) The images of mice ocular tissues of FP, FFA and H&E histological evaluation of mice retina at 400×; GCL, (IPL) Inner plexiform layer, (INL) Inner nuclear layer, (OPL), Outer plexiform layer, ONL, (PRL) Photoreceptor layer. (D) Relative <t>VEGF</t> protein expression levels in retinal tissues of mice, as determined by Western blotting and normalized <t>to</t> <t>β-actin.</t> All data were presented as mean ± SD ( n = 6), p values were determined using an unpaired, two-tailed Student's t -test, ** p < 0.01.
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a12303  (ABclonal Biotechnology)
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The therapeutic effect of SFB@(HB㊏EUD) on DR. (A) Results of the HET-CAM assay. (B) Body weight and blood glucose levels in different treatment mice groups. (C) The images of mice ocular tissues of FP, FFA and H&E histological evaluation of mice retina at 400×; GCL, (IPL) Inner plexiform layer, (INL) Inner nuclear layer, (OPL), Outer plexiform layer, ONL, (PRL) Photoreceptor layer. (D) Relative <t>VEGF</t> protein expression levels in retinal tissues of mice, as determined by Western blotting and normalized <t>to</t> <t>β-actin.</t> All data were presented as mean ± SD ( n = 6), p values were determined using an unpaired, two-tailed Student's t -test, ** p < 0.01.
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The therapeutic effect of SFB@(HB㊏EUD) on DR. (A) Results of the HET-CAM assay. (B) Body weight and blood glucose levels in different treatment mice groups. (C) The images of mice ocular tissues of FP, FFA and H&E histological evaluation of mice retina at 400×; GCL, (IPL) Inner plexiform layer, (INL) Inner nuclear layer, (OPL), Outer plexiform layer, ONL, (PRL) Photoreceptor layer. (D) Relative VEGF protein expression levels in retinal tissues of mice, as determined by Western blotting and normalized to β-actin. All data were presented as mean ± SD ( n = 6), p values were determined using an unpaired, two-tailed Student's t -test, ** p < 0.01.

Journal: International Journal of Pharmaceutics: X

Article Title: Sorafenib nanoparticles coated with Eudragit RL for ocular drug delivery: a potential treatment for diabetic retinopathy

doi: 10.1016/j.ijpx.2026.100523

Figure Lengend Snippet: The therapeutic effect of SFB@(HB㊏EUD) on DR. (A) Results of the HET-CAM assay. (B) Body weight and blood glucose levels in different treatment mice groups. (C) The images of mice ocular tissues of FP, FFA and H&E histological evaluation of mice retina at 400×; GCL, (IPL) Inner plexiform layer, (INL) Inner nuclear layer, (OPL), Outer plexiform layer, ONL, (PRL) Photoreceptor layer. (D) Relative VEGF protein expression levels in retinal tissues of mice, as determined by Western blotting and normalized to β-actin. All data were presented as mean ± SD ( n = 6), p values were determined using an unpaired, two-tailed Student's t -test, ** p < 0.01.

Article Snippet: Proteins were resolved by SDS-PAGE, transferred to a PVDF membrane, and probed with primary antibodies against VEGF (1:1000, ABclonal, A12303) and β-actin (1:1000, ABclonal, AC026).

Techniques: Chick Chorioallantoic Membrane Assay, Expressing, Western Blot, Two Tailed Test